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size=2>Please copy and paste the entire link which may be more than one line
long or the shorter tiny URL link in your browser's address
bar.<BR>__________________________________<BR><BR>Polycystic ovary syndrome in
men: Stein-Leventhal syndrome revisited.<BR><BR>Med Hypotheses.
2007;68(3):480-3<BR><BR>http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17134841&itool=pubmed_DocSum<BR><BR>or<BR><BR>http://preview.tinyurl.com/yuxa2v<BR><BR>Polycystic
ovary syndrome (PCOS), also referred to as Stein-Leventhal syndrome, is
characterized by hyperandrogenism, hyperinsulinemia, central obesity, polycystic
ovaries, and anovulation. However, some of these manifestations, including the
polycystic ovaries, are neither specific for the disorder, nor found in all
affected individuals. Since the primary defect underlying PCOS may be an
upstream endocrine and/or metabolic disturbance, rather than a defect in the
ovaries themselves, this study hypothesizes that this aberration can also arise
in men and that the absence of polycystic ovaries in men with other stigmata of
the disorder should not eliminate the diagnosis. Recognition of this
syndrome in men is important, since pharmacologic treatments identified for
women with PCOS may alleviate metabolic problems related to insulin resistance
and its sequelae in men with a similar underlying defect. This study
suggests that first-degree relatives of patients with PCOS should be examined
not only for phenotypic features characteristic of PCOS but also for biochemical
evidence of hyperinsulinemia and hyperandrogenism. In addition to examining
these individuals for obesity, the women should be evaluated for hirsutism and
the men should be screened for early-onset male-pattern alopecia and excess
hairiness. As new treatments for PCOS emerge, e.g. insulin-sensitizing
drugs, it will be important to determine if these treatments have beneficial
effects on the metabolic symptoms and complications in all afflicted patients,
regardless of gender.
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