[News] Obesity & IR mediates vascular dysfunction in women with PCOS

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Obesity and insulin  resistance but not hyperandrogenism mediates vascular 
dysfunction in women with  polycystic ovary syndrome.

Fertil Steril. 2006 Dec;86(6):1702-9. Epub  2006 Oct  24

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abst
ractPlus&list_uids=17067587&itool=pubmed_DocSum

PCOS  is associated with biochemical evidence of early atherosclerosis.  The  
study aimed to determine the contribution of hyperandrogenism, obesity, or  
insulin resistance to vascular dysfunction in women with PCOS. This  
comprehensive study demonstrates for the first time that obese women with PCOS  have 
markedly reduced vascular smooth muscle function compared to lean subjects  with 
PCOS. In our study obesity and insulin resistance, but not  hyperandrogenism, 
appeared to be significant modulators of vascular  function.
 
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