[News] Is metformin a primary ovulatory agent in patients with PCOS

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Is metformin a primary  ovulatory agent in patients with polycystic ovary 
syndrome?

Gynecol  Endocrinol. 2006  Nov;22(11):595-604

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abst
ractPlus&list_uids=17145645&itool=pubmed_DocSum

Insulin  resistance is common with PCOS. It contributes to the anovulation,  
hyperandrogenism, infertility and early pregnancy loss suffered by women with  
PCOS. Current evidence supports the role of metformin in the treatment of  
anovulation in PCOS. In addition, novel evidence suggests that insulin  
sensitizers may also play a role in reducing the risk of early pregnancy loss.  The 
insulin-sensitizing agents available commercially include metformin,  
rosiglitazone and pioglitazone. Metformin is the agent that has been most  frequently 
studied in PCOS, and has the most favorable pregnancy safety profile.  The study 
concludes that there is strong evidence supporting the use of  metformin as a 
primary ovulatory agent in women with PCOS.  

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