[News] Acute effects of metformin therapy include improvement of IR &ovarian morphology

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Acute effects of metformin therapy  include improvement of insulin resistance 
and ovarian morphology.

Fertil  Steril. 2007 Jan  12

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abst
ractPlus&list_uids=17224152&itool=pubmed_DocSum

This  study compared PCOS patients with (IR) and without (NIR) insulin 
resistance to  controls.  All were put on 850 mg of metformin per day for a week.   
Several blood tests were statistically significantly higher in patients with  
PCOS compared to controls. These same blood tests were similar among IR and 
NIR  patients with PCOS.  One week of metformin therapy did not alter the blood  
test levels. However, there was a statistically significant increase in  
glucose/insulin ratios, and a significant decrease in the number of   follicles 
after 1 week of metformin therapy.  The study concluded that  levels of these 
blood tests are significantly increased in patients with PCOS  compared to 
controls, but are not associated with insulin resistance. Low-dose  metformin 
therapy improves IR and polycystic ovary morphology, even though the  blood test 
levels remain unchanged.  

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