[News] Insulin resistance and metabolic profile in lean &overweight/obese PCOS Patients

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Insulin resistance and  metabolic profile in lean and overweight/obese 
polycystic ovary syndrome  patients

Arq Bras Endocrinol Metabol. 2006  Dec;50(6):1026-33

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abst
ractPlus&list_uids=17221108&itool=pubmed_DocSum

The  purpose of this study was to evaluate insulin sensitivity and the 
metabolic  features in normal weight and overweight/obese patients with PCOS.  The  
patients were divided into 2 groups.  The lean group had BMIs between 18.5  
and 24.9.  The obese / overweight group had BMIs between 25 and 40.   Higher 
blood pressure, insulin resistance indices, triglycerides and free  testosterone 
were found in the overweight / obese group.  Lower HDL levels  were also found 
in that group.   The study concluded obesity is  associated with insulin 
resistance and diabetes mellitus in PCOS. The absence of  correlation between the 
IR indices and the FT with the lipidic profile suggests  that other factors, 
such as the free fatty acids, can be involved in the  pathogenesis of 
dyslipidemia in PCOS



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