[News] Retinol-Binding Protein: A Molecule That Predicts IR & Type 2 Diabetes

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Retinol-Binding Protein: A Molecule That Predicts Insulin Resistance  and 
Type 2  Diabetes

http://general-medicine.jwatch.org/cgi/content/full/2006/630/1?q=etoc

N  Engl J Med 2006 Jun 15; 354:2552-63

In this study, it was found that  higher serum retinol-binding protein 4 
(RBP4) levels were associated strongly  with elements of the metabolic syndrome.  
RBP4 levels correlated strongly  with the degree of insulin resistance, 
regardless of body weight or other risk  factors.  And mouse studies indicate that 
RBP4 is a cause of insulin  resistance, not merely a correlate.  These findings 
likely will prompt a  search for drugs that can block the effects of RBP4, 
particularly on glucose use  by muscle. 
 
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