[News] The impact of obesity on reproduction in women with polycystic ovary syndrome

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The impact of obesity  on reproduction in women with polycystic ovary syndrome

BJOG. 2006  Oct;113(10):1148-59. Epub 2006 Jul  7

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abst
ractPlus&list_uids=16827825&itool=pubmed_DocSum

The  clinical features of PCOS are heterogeneous and may change throughout 
the life  span, starting from adolescence to postmenopausal age. This is largely 
dependent  on the influence of obesity and metabolic alterations, including 
an  insulin-resistant state and the metabolic syndrome, which consistently 
affect  most women with PCOS. Obesity does in fact have profound effects on both 
the  pathophysiology and the clinical manifestation of PCOS. Compared with 
normal  weight women with PCOS, those with obesity are characterized by a worsened 
 hyperandrogenic and metabolic state, poorer menses and ovulatory performance 
 and, ultimately, poorer pregnancy rates. The importance of obesity in the  
pathogenesis of PCOS is emphasized by the efficacy of lifestyle intervention 
and  weight loss, not only on metabolic alterations but also on 
hyperandrogenism,  ovulation and fertility.  

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