[News] Effects of carbamazepine & oxcarbazepine on the reproductive endocrine function

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Effects  of carbamazepine and oxcarbazepine on the reproductive endocrine 
function in  women with epilepsy

Epilepsia. 2006  Sep;47(9):1441-6

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abst
ractPlus&list_uids=16981858&itool=pubmed_DocSum

Carbamazepine  (CBZ) is the generic form of Tegretol.  Oxcarbazepine (OXC) is 
the generic  form of Trileptal.  These drugs are not only used to treat 
epilepsy, they  are also used as mood stabilizers.  The women taking CBZ or OXC had 
lower  serum testosterone levels and lower free androgen indexes than the 
control  subjects.  CBZ medication was associated with increased concentrations 
of  serum sex hormone-binding globulin (SHBG). The patients taking OXC had 
higher  concentrations of dehydroepiandrosterone sulfate (DHEAS) and 
androstendione than  did the women taking CBZ. The prevalence of polycystic ovaries was 
high in those  treated with OXC.  These findings suggest that OXC may be 
disadvantageous  for women with epilepsy and hyperandrogenism, whereas CBZ may be 
beneficial for  these women.  

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